 |
||
 |
|
|
UTRŪtech
UTRŪtech offers a new approach to establish high-yield protein production in mammalian cell systems.
Using selected targeting elements and state-of-the-art genetic engineering techniques (UTRŪtech), the cells' protein synthetic machinery and secretory pathway are efficiently exploited, leading to high production rates of any protein of interest.
Different targeting elements were shown to result in model-protein yields with up to 50-fold differences.
The incorporation of UTRŪtech in a highly optimised industrial mammalian expression system gave 50% increased productivity.
Achievements
- Significant increase of human monoclonal antibody production
- Significant increase of human EPO production
- Efficient secretion of an intracellular model protein
Complementarity
UTRŪtech can bring improvements incremental to results previously achieved with other 'high expression' approaches, such as modulation of cell growth conditions or transcriptional enhancement.
Application range
UTRŪtech has a broad application range. In addition to boosting protein production, its potential in e.g. gene therapy has been demonstrated.