Although in recent years mammalian expression systems have been substantially improved, bottlenecks do remain. The experience we have gathered from various industrial collaborations and long-standing research work enables us to address this challenge. Based on the technology we have developed, the following tools and services are offered:
Tools >>
Proprietary targeting elements mediating increased protein synthesis/secretion
UTR®Tech and UTR®Betatech to be readily incorporated into the customer's expression vector.
Services >>
Vector improvement
Generating a vector optimization scheme, and subsequent incorporation of the selected tools and performance testing.
Tailor-made vectors for individual proteins.
Using UTR®Tailortech for generation of a high-yield variant of the customer's vector for the protein of interest.
Production of (difficult-to-express) tool-proteins
Using our know-how and proprietary tools to achieve adequate amounts of tool-proteins, including challenging proteins, such as certain intracellular and toxic proteins (up to 100mg depending on the expressablility of the individual proteins).